Simple 4-nitro-1,8-naphthalimide derivatives efficiently and almost quantitatively liberate nitrite upon reaction with glutathione (GSH). These compounds function as NO prodrugs, enhancing NO bioavailability in mammalian cells through intracellular nitrite-to-NO conversion.

Naphthalene-1,8-peridichalcogenides mediate a six-electron reduction of organic nitro compounds to produce the corresponding primary amines at physiologically relevant temperature (37 °C) using water as the solvent. They also mediate the reduction of azides to amines.

This paper describes a series of fluorescent probes capable of effectively monitoring alkaline phosphatase (ALP) activity in mammalian cells with high sensitivity and selectivity.

The development of GPX4 functional mimetics represents a promising strategy to prevent ferroptosis and its associated pathologies. In this paper, the translational potential of GPX4 functional mimetic for targeting ferroptosis-driven neurodegenerative disorders is discussed.

Chalcogen bonding (ChB) and its directionality can be used as a driving force to improve the cellular uptake of small molecules. The uptake of selenium and tellurium compounds was found to be remarkably higher than that of their oxygen and sulfur analogues.

Vanadia nanozymes with specific and morphology-dependent GPx activity effectively inhibit the aggregation of human platelets and prevent pulmonary thromboembolism in mice.

The deiodination of thyroid hormones with peri-substituted naphthalene diselenol reveal that the regioselectivity towards iodine is not altered upon introduction of more electronegative halogens (F, Cl and Br), reinforcing the concept of halogen bonding in the deiodination reactions.

The recent advances and the mechanistic aspects of intracellular delivery and role of non-covalent interactions during the cellular uptake of proteins and small molecules are described.

A highly selective fluorescent probe has been developed for monitoring thyroid hormone transporter activity in mammalian cells. The probe selectivity recognizes the monocarboxylate transporter 8 (MCT8) in various cell lines.

The SOD mimetic CeVO4 nanozymes effectively regulate the bioavailability of both NO and superoxide, the two key constitutive molecules of vascular endothelium, even in the absence of the cellular SOD enzyme.

The advances in the development of redox-active nanozymes and their biomedical applications are described. We highlight the therapeutic significance of the antioxidant and prooxidant nanozymes in various diseases such as cancer, neurodegeneration, and cardiovascular diseases.

The modulation of the electronic properties of the iodine atoms in thyroxine (T4) through the phenolic group has a remarkable influence on the regioselectivity of the deiodination.